- When planning pregnancy, it is important to know that a number of drugs can affect fertility both in man and in woman
- Drugs for the treatment of e.g. rheumatoid arthritis and other chronic diseases can affect fertility and the development of malformations, and therefore should be avoided as a starting point
- In these cases it is important to contact the practitioner to get risk elucidated and decide the possibility of other treatments
Medication may affect conception
When planning pregnancy, it is important not only to focus on the woman’s health. There are medications that can affect both the woman and the man. In the woman they can reduce the chance of pregnancy, and it can increase the risk of spontaneous abortions and damage in the fetus. With such medications can reduce the number of man spermier, and thus the chance of getting pregnant, but a few preparations can also cause abortions or congenital damage in the fetus.
Medications that affect the woman and the man in this way is, first and foremost, medications used in the treatment of rheumatic diseases-DMARDs, disease modifying anti-rheumatic drugs. The preparations, however, also be used by other diseases. If you are using such preparations, you should be aware of the risk they pose, in relation to pregnancy and breastfeeding.
This drug affects both eggs and sperm. It can also cause miscarriage or birth defects such as spina bifida (spina bifida) in the unborn child. Use of safe contraception is therefore important, while using methotrexate-either you are male or female. Methotrexate should not be taken during pregnancy or lactation.
Treatment with methotrexate should be stopped at least 3 months (some doctors recommend up to 6 months) before you trying to get pregnant or father a child. Some doctors believe that it is enough with 8 week break before a woman who has been methotrexate, can try to achieve pregnancy.
When it comes to men, is that individual who advises at least 4 months without medication, before you can try to achieve pregnancy. These recommendations are based on the existing literature.
You become pregnant while you are taking methotrexate, you should seek medical attention.
This preparation can reduce the number of sperm in men, and it can affect a woman’s eggs. However, it seems that women taking azathioprine, give birth to normal children, and there doesn’t seem to be at increased risk of congenital defects. Nevertheless, it is recommended not to take azatioprin during pregnancy, or as long as you are breastfeeding.
Ciklosporin is used frequently among patients who have undergone transplants and for arthritis treatment. Many women who have used this medication in pregnancy, have had successful pregnancies. It is excreted in breast milk, and there is therefore recommended bottle of nutrition to the baby.
Cyklofosfamid and klorambucil
Cyklofosfamid and klorambucil can cause sterility in both men and women. Men who take these medications, it is advisable for freezing sperm before treatment starts, so that sperm can be used by future fertilization. For women who need to be treated with these preparations, recommended freezing of ovarian tissue before treatment. Use of such medications should be discontinued at least 3 months before trying to get pregnant. Funds should also be avoided during pregnancy because they can cause deformities. Bottle of nutrition is recommended, if you take these preparations, after the baby is born.
Leflunomide is relatively new in the treatment of rheumatoid arthritis. Leflunomide can cause birth defects and should be avoided both before and during pregnancy. Safe contraception should be used, as long as you consume this drug. Leflunomide becomes long in the body, and women who want to become pregnant, should wait at least 2 years after they stop taking this drug for those trying to conceive. For this reason, there are physicians who avoid to print this product to women who have pregnancy desired in the future. The waiting time can be reduced to 3 months, if you take a special treatment which washes out the medication from your body.
Men should discontinue taking preparation, browse through leaching treatment and then wait 3 months before trying to get pregnant.
Leflunomide should not be used during breastfeeding.
Many women have had successful pregnancies, while they have used this drug. However, there is a risk that it can cause problems if taken in high doses in early pregnancy, and therefore not recommended.
Sulfasalazine reduces the quantity of sperm, but the number rises again when treatment ceases. If a man has a hard time being a father, it may make sense to switch drug type. Many women have used this preparation during pregnancy and breastfeeding without problems.
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